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重磅免疫检查点CTLA-4 (E2V1Z) Rabbit mAb上市 | CST 12月新品上市

2021/12/23 14:02:03      点击:

Dec. 2021

热门新产品

CTLA-4 (E2V1Z) Rabbit mAb #53560

货号 规格 2021 年目录价
53560T
20 µl ¥1,400.00
53560S 100 µl ¥3,850.00 


CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893

货号 规格 2021 年目录价
26893SF
100 µg ¥7,400.00


细胞毒性 T 淋巴细胞蛋白 4 (CTLA-4, CD152) 是 Ig 超家族的一员,能够负向调控 T 细胞的早期激活 (1-4)。CTLA-4 蛋白主要在 T 细胞中表达,包括 CD8+ 细胞毒性 T 细胞、CD4+ 辅助 T 细胞和 CD4+/FoxP3+ 调节性 T 细胞(1,2)。CTLA-4 蛋白与 CD28 在细胞表面争相结合 B7.1 (CD80) 和 B7.2 (CD86),导致 T 细胞活性下调 (5)。CTLA-4 下游 SHP-2 和 PP2A 的激活会减弱 TCR 信号转导 (6)。研究表明,CTLA4 敲除小鼠患有引起过早死亡的淋巴组织增殖性疾病,表明 CTLA-4 可负向调控 T 细胞 (7)。相应 CTLA4 基因突变与多种疾病有关,包括胰岛素依赖性糖尿病、格雷夫斯病、桥本甲状腺炎、乳糜泻、系统性红斑狼疮和 V 型自身免疫性淋巴细胞增殖性综合征 (8,9)。其他研究表明,CTLA-4 阻滞是肿瘤免疫治疗的有效策略 (10-12)。 


CST CTLA-4 (E2V1Z) Rabbit mAb #53560 的重要性:CTLA-4 是免疫治疗领域一个非常重要的转化医学相关靶点。研究人员需要观察肿瘤组织微环境中该靶标的表达情况,以识别肿瘤微环境当中免疫细胞的表型和功能。CST CTLA-4 抗体(#53560)是目前市面上两款用于 IHC-P应用的科研抗体之一,在十多种癌症组织样本当中进行了严格的验证  (滑动查看下方验证数据),适用于手动和基于自动染色机的免疫组化实验,是性价比之选。


同时,无载体配方CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893 也可以满足包括质谱流式,成像质谱流式等各种需要特殊抗体偶联的需求,是助力研究人员深入了解肿瘤免疫以及肿瘤微环境并开展转化医学研究的不二选择。


更多信息查看:CTLA-4 (E2V1Z) Rabbit mAb #53560CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893关键词ECM, Extracellular matrix, collage, minor fibrillar collagen, bone and cartilage development
12月新品列表 

产品货号

产品名称

实验应

Adhesion / ECM
63034S

COL3A1 (E8D7R) XP® Rabbit mAb

WB, IHC-P

H

74978S

MUC5B (E4Y5Z) Rabbit mAb

IHC-P, IF-IC

H

44454S

MUC13 (E6Z1K) Rabbit mAb

WB, IP, IHC-P, IF-IC

H

49536S

PAI-1 (E3I5H) XP® Rabbit mAb

WB, IHC-P

H

20302S

Periostin (E5F2S) Rabbit mAb

WB, IP, IHC-P

H

Apoptosis

40618S Gasdermin E Antibody WB M, R
88169S Mcl-1 (D2W9E) Rabbit mAb (Alexa Fluor® 594 Conjugate) IF-IC, F H, M, R
66026S PARP (46D11) Rabbit mAb (Alexa Fluor® 488 Conjugate) F H, M, R, Mk
53727S PARP (46D11) Rabbit mAb (Alexa Fluor® 594 Conjugate) F H, M, R, Mk
34366S PARP (46D11) Rabbit mAb (Alexa Fluor® 647 Conjugate) F H, M, R, Mk
58274S Phospho-RIP (Ser320) Antibody WB H

Autophagy

80158S

CCPG1 (E3C5G) Rabbit mAb

WB, IP

H

12074S Phospho-SQSTM1/p62 (Ser349) (E7M1A) Rabbit mAb (Alexa Fluor® 488 Conjugate) IF-IC, F H, M, (R)

Ca, cAMP and Lipid Signaling

37067S

PhosphoPlus® PLCγ2 (Tyr759) Antibody Duet

-

-

Cell Cycle / Checkpoint Control

99274S

Phospho-Rb (Ser807) Antibody

WB

H

76998S

XRCC1 (E4A3V) XP® Rabbit mAb

WB, IP, IHC-P, IF-IC

H, M, R

Chromatin Regulation / Nuclear Function

50607S

FTSJ3 (E6T9J) Rabbit mAb WB H, M

20123S

Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor® 555 Conjugate)

F

H, M, R, Mk, (X, Z)

10584S

Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor® 594 Conjugate)

F

H, M, R, Mk, (X, Z)

88197C FastScan™ LbCpf1 (Strain ND2006) ELISA Kit ELISA -

34907S

MLL1 (E9W9Z) Rabbit mAb (Carboxy-terminal Antigen)

WB, IP, ChIP

H, Mk

79030S

TIF1α/TRIM24 (E9T3N) Rabbit mAb

WB, IP, IHC-P

H, M, R, Mk

92145S

TTF-I Antibody

WB

H, M, R, Mk

Cytoskeletal Signaling

47610S KIF5B (E3H4J) Rabbit mAb WB, IF-IC H, M, R
62696S KIF5B (E4A5A) Rabbit mAb WB, IP, IF-IC H
47293S SETD3 Antibody WB, IP H, Mk
37430S ZNF185 (E6W4I) Rabbit mAb WB, IP, IF-IC H
86942S ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor® 488 Conjugate) IF-IC H, Mk
98225S ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor® 647 Conjugate) IF-IC H, Mk

Developmental Biology

64022S

CD15/SSEA1 (MC480) Mouse mAb (Alexa Fluor® 488 Conjugate)

IF-IC, F

M

16274S

ETV5 (E5G9V) Rabbit mAb

WB, IP

H, M

54319S

Human FGF-9 Recombinant Protein

-

-

74356S

Mouse FGF-9 Recombinant Protein

-

-

41560S

HIF-1α (D1S7W) XP® Rabbit mAb (Biotinylated)

WB

H, M, Mk

70948S

Notch2 (D76A6) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate)

IF-IC, F

H, M, R

36135S

POU2F3 (E5N2D) XP® Rabbit mAb

WB, IHC-Bond, IHC-P

H

18113S

RUNX3/AML2 (E8D5W) XP® Rabbit mAb

WB, IP, IHC-P

H

44909S

Human TGF-α Recombinant Protein

-

-

10179S

YAP/TAZ (D24E4) Rabbit mAb (Alexa Fluor® 647 Conjugate)

F

H, M, Mk

Glucose / Energy Metabolism

66933S GPAT4 Antibody WB H

Immunology and Inflammation

81123S ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor® 555 Conjugate) F M
29956S ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor® 594 Conjugate) F M
90776S Bcl-3 (E2M6N) Rabbit mAb WB, F H
16611S Bcl-3 (E4D4K) Rabbit mAb WB, IP, IHC-P H, M
64137S Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (Alexa Fluor® 647 Conjugate) F H
16803S Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (PE Conjugate) F H
88083S CD3ζ Antibody WB H, M
23578S CD27 Antibody WB M
26233S CD34 (E2J1K) Rabbit mAb WB, IF-F, IF-IC M
46894S CD37 (E4K2M) Rabbit mAb WB, IP, F H
55084S CD74 (D5N3I) XP® Rabbit mAb (PE Conjugate) F H
89660S Phospho-CD79A (Tyr210) (E8E9Z) Rabbit mAb WB, F H
57950S CLEC12A/CLL-1 (E5T5V) Rabbit mAb WB, IP, F H

53560S

CTLA-4 (E2V1Z) Rabbit mAb

WB, IP, IHC-Bond, IHC-P

H, M

26893SF

CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) 

WB, IHC

H, M

87223S DPEP-1/MDP (E4O6J) XP® Rabbit mAb WB, IHC-P, IF-IC H
76290S DPEP-1/MDP (E5C2V) Rabbit mAb WB, IF-IC H
78401S FcRγ (E6Y1A) Rabbit mAb WB, IP, IHC-Bond, IHC-P, IF-F, IF-IC H, M
20085S FcRn (E4D5I) Rabbit mAb WB, IHC-P M, R
45850S Fibrinogen gamma chain (E1U3Z) XP® Rabbit mAb WB, IHC-Bond, IHC-P H
89572S Galectin-3/LGALS3 (E7B6R) Rabbit mAb WB, IP, IHC-P, IF-F, IF-IC H, M, R
99695S Granzyme H (E3H7W) Rabbit mAb WB, F H
61606S HPK1 (E1C3L) Rabbit mAb (Biotinylated) WB H
18526S IL-2Rγ (E2Z5W) Rabbit mAb WB, IP, F M
57529S Human IL-11 Recombinant Protein - -
76561S Mouse IL-11 Recombinant Protein - -
68350S Integrin α11 Antibody WB, IP H
98344S IRF-8 (E8X4K) Rabbit mAb WB, IP, IF-F, IF-IC, F, ChIP H, M, R
51817S ITK (E4X7M) Rabbit mAb (Biotinylated) WB H

89368S

LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor® 488 Conjugate)

IF-F, IF-IC

M

73294S LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor® 594 Conjugate) IF-F, IF-IC M
98215S MSR1 (E7P6W) Rabbit mAb IHC-P M
10054S NEK7 Antibody WB H, M
96874S Phospho-NF-κB p65 (Ser529) Antibody WB H
84223T Human Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit - -
97624T Mouse Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit - -

73582C

PathScan® Phospho-Stat1 (Tyr701) Sandwich ELISA Kit ELISA H, M
73452S Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) F H, M, R, Mk, (Hm, B, Pg, Hr)
61958S Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (Alexa Fluor® 594 Conjugate) F H, M, R, Mk, (Hm, B, Pg, Hr)
72337S TNF-R2 (E8D7P) Rabbit mAb WB, IP, F H
38519S Toll-like Receptor 4 (E5D8T) Rabbit mAb WB H
58125S Tox (E5J8A) Rabbit mAb IF-IC, F H

Infectious Diseases

74698S SARS-CoV-2 Envelope Protein Antibody WB Vir
37393C PathScan® SARS-CoV-2 Nucleocapsid Protein Sandwich ELISA Kit ELISA Vir
34340S SARS-CoV-2 ORF3a Antibody WB, IP Vir

MAP Kinase Signaling

40737S

MEK5 (E4C4B) Rabbit mAb WB, IP H, M, R

Metabolism

58662S

AGK Antibody WB H
24972S AIFM2/FSP1 Antibody WB H
31219S COX2/MT-CO2 Antibody WB, IP H, Mk
26381S DHODH (E9X8R) Rabbit mAb WB H, M, R
17412S MT-ATP8 Antibody WB, IP H
45535S Perilipin-2 Antibody WB, IP H
65675S TOM70 Antibody WB H, M, R
53370S Xanthine Dehydrogenase/Oxidase Antibody WB H

Motif Antibodies

46784S

PTMScan® HS Acetyl-Lysine Motif (Ac-K) Kit

-

-

Neuroscience

56161C

PathScan® β-Amyloid (1-40) Sandwich ELISA Kit

ELISA

H

49285S

ApoE (E7X2A) Rabbit mAb

WB, IP, IHC-P, IF-F, IF-IC

M

80718S DNAJC7 Antibody WB H, M, R
90963S Neurexin-3 Antibody WB H, M, R

51510T

α-Synuclein (E4U2F) XP® Rabbit mAb

WB, IP, IHC-P, IF-F, IF-IC

H, M, R

98863T

TREM2-dependent mTOR Metabolic Fitness Antibody Sampler Kit

-

-

RTK

96453S Phospho-Axl (Tyr779) Antibody WB, IP H
76799S HER2/ErbB2 (CB11) Mouse mAb IHC-Bond, IHC-P H

Translational Control

41025S ADAR1 (E6X9R) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) IF-IC, F H, Mk
31358S

DIMT1 Antibody

WB

H, M, R, Mk

Ubiquitin and Ubiquitin-like proteins

17579S PSMB10/MECL-1 (E6R7O) Rabbit mAb WB H, M

Related Products

20533S

10% SDS Solution

C&R

-

5708S Anti-biotin (D5A7) Rabbit mAb (Alexa Fluor® 488 Conjugate) F All

7005S

Glycine Solution (10X)

ChIP, C&R

-

20664S His-Tag (D3I1O) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) IF-IC, F All
81940S His-Tag (D3I1O) XP® Rabbit mAb (Alexa Fluor® 594 Conjugate) IF-IC, F All
67476S V5-Tag (D3H8Q) Rabbit mAb (Sepharose® Bead Conjugate) IP All
83862S V5-Tag (E9H8O) Mouse mAb (Sepharose® Bead Conjugate) IP All

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